Federal officials are warning about a dangerous new synthetic opioid that’s already been linked to dozens of deaths, and could spread further across the country. The White House Office of National Drug Control Policy has issued a national alert about cychlorphine, a powerful opioid now showing up in the illicit drug supply.

Authorities say the drug has already been connected to at least 55 deaths nationwide between 2025 and 2026. Cychlorphine is especially concerning because it’s estimated to be up to ten times more potent than fentanyl, and overdoses may require multiple doses of naloxone to reverse.

Officials say the drug has been detected in multiple states across all four regions of the country, with higher concentrations in the Midwest, South, and Northeast, including states like Ohio, Texas, and Tennessee.

In some cases, it’s being mixed with other drugs like methamphetamine, cocaine, and fentanyl, making it even more dangerous and unpredictable. Adding to the concern, cychlorphine is not reliably detected by common drug test strips or standard hospital screenings. Health officials and first responders are being urged to stay alert, carry naloxone, and be prepared to administer multiple doses during an overdose emergency.

The public is also reminded, if someone shows signs of an overdose, call 9-1-1 immediately. For guidance on poisoning or exposure, the national Poison Control hotline is 1-800-222-1222.